Focus on the Controversial Aspects of 64Cu-ATSM in Tumoral Hypoxia Mapping by PET Imaging
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منابع مشابه
Focus on the Controversial Aspects of 64Cu-ATSM in Tumoral Hypoxia Mapping by PET Imaging
Mapping tumor hypoxia is a great challenge in positron emission tomography (PET) imaging as the precise functional information of the biological processes is needed for many effective therapeutic strategies. Tumor hypoxia has been widely reported as a poor prognostic indicator and is often associated with tumor aggressiveness, chemo- and radio-resistance. An accurate diagnosis of hypoxia is a c...
متن کاملCardiac hypoxia imaging: second-generation analogues of 64Cu-ATSM.
UNLABELLED Myocardial hypoxia is an attractive target for diagnostic and prognostic imaging, but current approaches are insufficiently sensitive for clinical use. The PET tracer copper(II)-diacetyl-bis(N4-methylthiosemicarbazone) ((64)Cu-ATSM) has promise, but its selectivity and sensitivity could be improved by structural modification. We have therefore evaluated a range of (64)Cu-ATSM analogs...
متن کامل64Cu-ATSM and 18FDG PET uptake and 64Cu-ATSM autoradiography in spontaneous canine tumors: comparison with pimonidazole hypoxia immunohistochemistry
BACKGROUND The aim of this study was to compare (64)Cu-diacetyl-bis(N(4)-methylsemicarbazone) ((64)Cu-ATSM) and (18)FDG PET uptake characteristics and (64)Cu-ATSM autoradiography to pimonidazole immunohistochemistry in spontaneous canine sarcomas and carcinomas. METHODS Biopsies were collected from individual tumors between approximately 3 and 25 hours after the intravenous injection of (64)C...
متن کاملContribution of [64Cu]-ATSM PET in molecular imaging of tumour hypoxia compared to classical [18F]-MISO--a selected review.
During the carcinogenesis process, tumour cells often have a more rapid proliferation potential than cells that participate in blood capillary formation by neoangiogenesis. As a consequence of the poorly organized vasculature of various solid tumours, a limited oxygen delivery is observed. This hypoxic mechanism frequently occurs in solid cancers and can lead to therapeutic resistance. The pres...
متن کاملPET/MR imaging of hypoxic atherosclerosis using 64Cu-ATSM in a rabbit model
ATSM in a rabbit model Xingyu Nie1, 2, Richard Laforest1, Andrew Elvington3, Gwendalyn J. Randolph3, Jie Zheng1, Tom Voller1, Dana R. Abendschein3,4, Suzanne E. Lapi1, 2, 3, Pamela K. Woodard1, 2, 5 Affiliations 1. Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA 2. Department of Biomedical Engineering, Washington University in St. Louis, MO, USA...
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ژورنال
عنوان ژورنال: Frontiers in Medicine
سال: 2015
ISSN: 2296-858X
DOI: 10.3389/fmed.2015.00058